Alzheimer'S History
The Alzheimer's history began in the early 1900s - in 1906, to be exact. That year, Alois Alzheimer (1864-1915), a German physician well-known for his extensive work in neuropathology and histopathology with other almighty names in science, marked the Alzheimer's history by describing a condition of a certain middle aged patient of his. The patient, named Auguste Deter, was only 55 years old when she died for factors that puzzled her attending physicians, including Alzheimer himself. Her condition involved progressive troubles with memory, language, and behavior. Little did anybody know that it will be her death that would signal the start of the Alzheimer's history. After the death of Auguste D., Alzheimer, who was in Munich at the time, studied her brain to determine what the reasons that caused her symptoms to appear were. There he found two modifications in the tissue of the brain. During the course of the Alzheimer's history, these two modifications would later become the vital features of this brain disease. First are the tangles. Called Neurofibrillary tangles, these formations are intracellular abnormalities involving the cytoplasm of the nerve cell. In order to observe them, one would have to use hematoxylin and eosin stain or via silver impregnation techniques, as well as Congo red or fluorescent dye thioflavine. These abnormalities are generally found in the cerebral cortex, especially in the temporal lobe structures such s the hippocampus and amygdale. The second alteration that Alzheimer observed is the neuritic plaques. In the Alzheimer's history, it has been found that these neuritic plaques are actually made up of protein called amyloid, which is naturally found in the body. But for factors yet unknown, large deposits of this protein are formed between the nerve cells. Later, it was also discovered that the plaques also contained deposits of aluminum silicate, in addition to amyloid peptides, hence the term "amyloid plaques." This, along neurofibrillary tangles, are said to cause the symptoms of Alzheimer's. Years after Alzheimer first described these vital features of the disease, scientists have gained greater insight into the genetic reasons that add to Alzheimer's disease. In this period of Alzheimer's history, it has been found that there is a form of the disease that is mostly hereditary - that is, it's passed from one family member to another through their genetic makeup. But much is still to be learned about Alzheimer's history before any real conclusions can be made. And at present, the research on Alzheimer's disease is more focused on finding methods to prevent the onset of the symptoms. |
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